Nature

Systematic Reviews and Clinical Trials in Health Research

Systematic reviews and clinical trials form the cornerstone of contemporary health research, providing robust, evidence‐based insights that guide clinical practice and policy. Systematic reviews ...
CMAJ

Observer bias in randomized clinical trials with measurement scale outcomes: a systematic review of trials with both blinded and nonblinded assessors

Background: Clinical trials are commonly done without blinded outcome assessors despite the risk of bias. We wanted to evaluate the effect of nonblinded outcome assessment on estimated effects in ...
ascopubs.org

Evolution of Clinical Trial Design in Early Drug Development: Systematic Review of Expansion Cohort Use in Single-Agent Phase I Cancer Trials

Tumor-Infiltrating Lymphocyte Grade in Primary Melanomas Is Independently Associated With Melanoma-Specific Survival in the Population-Based Genes, Environment and Melanoma Study We identified 611 ...
ascopubs.org

Pain Management in Cancer Center Inpatients: A Cluster Randomized Trial to Evaluate a Systematic Integrated Approach—The Edinburgh Pain Assessment and Management Tool

Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial Ten centers ...
BMJ

A systematic review and meta-analysis of clinical trials on physical interventions for lateral epicondylalgia

1 Division of Physiotherapy, University of Queensland, St Lucia, Queensland, Australia 2 Musculoskeletal Pain and Injury Research Unit, Division of Physiotherapy, University of Queensland A systematic ...
BMJ

Exercise based cardiac rehabilitation for atrial fibrillation: Cochrane systematic review, meta-analysis, meta-regression and trial sequential analysis

Objective To undertake a contemporary review of the impact of exercise based cardiac rehabilitation (ExCR) for patients with atrial fibrillation (AF). Data sources CENTRAL, MEDLINE, Embase, PsycINFO, ...