T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

Single-molecule imaging shows that three CBX2 protein molecules can seed Polycomb condensates that silence genes in stem cells. The discovery reveals how rare proteins organize genome regulation and ...

Northwestern Medicine scientists have identified the cellular mechanisms that cause immune cells to differentiate and ultimately lose function during viral infection, findings that could improve ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

The mechanism for muscle stem cells repair could inspire therapeutics for muscle loss caused by injury, aging and weight-loss medications.